加味归肾优化方治疗早发性卵巢功能不全的疗效与机制：m6A修饰与氧化应激

ClinicalTrials.gov · 2026年9月25日 · Yun

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一分钟了解要点早期1期试验将评估加味归肾优化方治疗早发性卵巢功能不全的疗效及m6A修饰和氧化应激机制。

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摘要Abstract

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Brief summary: The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency (POI). The main question it aims to answer is: Does JJGS improve ovarian function in women with POI after three menstrual cycles of treatment? Twenty-five women with POI will receive JJGS, and 20 healthy women will serve as controls. Changes in FSH, E2, LH, AMH, oxidative stress markers, plasma FTO levels, whole-blood RNA m6A levels, and symptom scores will be analyzed before and after treatment.

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Conditions: Premature Ovarian Insufficiency

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Interventions: drug: JJGS

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Phase: Early Phase 1

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Enrollment: 45 (estimated)

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Sponsor: Shi Yun (other)

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Countries: China

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Status: not yet recruiting

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