GDNF 家族：信号传导、生物学功能与治疗价值
The GDNF family: signalling, biological functions and therapeutic value
本文系统回顾了神经生长因子（NGF）家族和胶质细胞源性神经营养因子（GDNF）家族的信号传导机制与生物学功能。GDNF 家族配体通过 Ret 受体酪氨酸激酶等激活细胞内信号通路，对中枢和外周神经元的发育与维持至关重要。小鼠基因敲除研究表明这两个家族可能在同一神经元中协同或序贯发挥作用。文章还讨论了这些神经营养因子的治疗价值，为后续神经退行性疾病的基因治疗研究提供了理论基础。
为什么推荐给您：2002 年发表的综述性文章，总结已有知识，不包含新发现或新技术。
不需要生物学背景，多打比方
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摘要Abstract
Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families comprising neurotrophins and GDNF-family ligands (GFLs), respectively are crucial for the development and maintenance of distinct sets of central and peripheral neurons. Knockout studies in the mouse have revealed that members of these two families might collaborate or act sequentially in a given neuron. Although neurotrophins and GFLs activate common intracellular signalling pathways through their receptor tyrosine kinases, several clear differences exist between these families of trophic factors.