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美国猪肾异种移植首次临床试验的建议患者选择标准
Suggested Patient Selection Criteria for Initial Clinical Trials of Pig Kidney Xenotransplantation in the United States
作者：Abhijit Jagdale, Vineeta Kumar, Douglas J Anderson, Jayme E Locke, Michael J Hanaway, Devin E Eckhoff, Hayato Iwase, David K C Cooper
Transplantation · 2021年9月1日 · Jagdale 等 8 位作者
不需要生物学背景，多打比方
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摘要Abstract
There is a critical shortage of kidneys for transplantation into patients with kidney failure. Genetically-engineered pigs could provide an additional source. Increasing success is being reported of the transplantation of pig kidneys in nonhuman primates. Consideration is now being given to the selection of patients for the first clinical trial of pig kidney transplantation. In some US states, patients aged 55–65, particularly if of blood group O, may wait >5 years for a donor organ, by which time >50% are likely to have died or removed from the wait-list because they are no longer acceptable for transplantation. We suggest these patients, if otherwise healthy, might accept the opportunity of early pig kidney transplantation.
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