用神经假体在瘫痪后恢复快速自然双手打字
Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis
键盘打字是熟悉的、信息传递效率很高的交流方式，但瘫痪者无法完成。研究者开发了一种植入大脑皮层的脑机接口打字神经假体，患者只需想象手指动作，系统即可解读出想按的按键，用约30个校准句子就能训练出可用的解读模型，并用5元语言模型进一步提升整句识别。两名四肢瘫痪（一为渐冻症、一为脊髓损伤）的临床试验受试者使用该系统，打字速度可达每分钟110个字符、约合每分钟22个词，词错误率仅1.6%。这已达到健康人打字的准确度水平，且比现有手部运动脑机接口的信息传输率更高。
为什么推荐给您：新型双手打字脑机接口神经假体在两名瘫痪受试者中取得接近健康人的速度与准确度。
不需要生物学背景，多打比方
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摘要Abstract
Here, recognizing keyboard typing as a familiar, high information rate communication paradigm, we developed an intracortical brain-computer interface (iBCI) typing neuroprosthesis providing bimanual QWERTY keyboard functionality for people with paralysis. Typing with this iBCI involves only attempted finger movements, which are decoded accurately with as few as 30 calibration sentences. Sentence decoding is improved using a 5-gram language model. This typing neuroprosthesis performed well for two iBCI clinical trial participants with tetraplegia-one with amyotrophic lateral sclerosis and one with spinal cord injury. Typing speed is user-regulated, reaching 110 characters per minute, resulting in 22 words per minute with a word error rate of 1.6%. This resembles able-bodied typing accuracy and provides higher throughput than current state-of-the-art hand motor iBCI decoding. In summary, a typing neuroprosthesis decoding finger movements, provides an intuitive, familiar and easy-to-learn paradigm for individuals with impaired communication due to paralysis.