一种可植入的无线无电池空间选择性迷走神经刺激器
An Implantable Wireless Battery-Free Spatially Selective Vagus Nerve Stimulator
bioRxiv · 2026 年 9 月 15 日 · Edvards Rutkovskis, Enrico Ravagli, Henry Lancashire 等 15 人
迷走神经刺激（通过电极刺激颈部迷走神经治疗疾病）已用于难治性癫痫等，但非选择性刺激会激活无关神经分支，产生副作用。本研究开发了一种近场通信供电、无电池、可临时植入的多通道刺激装置，配合15通道袖带电极，可选择性刺激神经的特定区域。在4头猪和1名人类受试者中测试，猪出现23.28±12.91%的选择性心动过缓，人类受试者为7.5%，且心脏与喉部反应在神经圆周上相隔231度，实现了效应分离。这证明无线无电池选择性迷走神经刺激在人体可行，有望用于心衰等自主神经疾病，但尚属早期探索、未经过同行评审。
为什么推荐给您：无线无电池选择性迷走神经刺激装置首次在人体验证，属新模态早期人体阳性结果。
不需要生物学背景，多打比方
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摘要Abstract
OBJECTIVE: Vagus nerve stimulation (VNS) is an established clinical therapy for drug-resistant epilepsy and other inflammatory conditions. However, off-target stimulation can produce unwanted side effects that limit therapeutic stimulation and hinder the development of new neuromodulation therapies. Selective VNS (sVNS) offers a strategy to reduce off-target organ activation; however, this approach is not available in humans, and no implantable or portable devices exist to trial sVNS in the clinical setup. This work aimed to design, manufacture, and validate an implantable wireless, battery-free stimulator with a selectively addressable output stage for targeted current delivery to specific regions of the human vagus nerve (VN).
APPROACH: We developed a near-field communication-controlled, wirelessly powered, battery-free, temporary implantable multichannel stimulation device, compatible with a 15-channel sVNS cuff electrode (14 selective electrode pairs and one circumferential whole-nerve channel). The device was encapsulated for short-term implantation and evaluated through benchtop characterisation, accelerated ageing, and validation in an acute porcine and a pilot human study.
MAIN RESULT: The sVNS device was evaluated in a porcine (n = 4) trial and a first-in-human pilot study (n = 1). Selective bradycardia of 23.28 ± 12.91% was observed in pigs and 7.5% in the human participant. In the human, a clear separation of bradycardic and tachycardic effects was observed, with additional selectivity in laryngeal activity. Cardiac and laryngeal responses were separated by 231° around the circumference of the nerve.
SIGNIFICANCE: This work demonstrates the feasibility of wireless battery-free sVNS for cardiac applications using a temporary implantable device. Geometrically selective stimulation has the potential to improve therapeutic efficacy while reducing stimulation-related side effects, and may facilitate future therapies for heart failure and other autonomic disorders.