BC200基因逃逸进入人类痘病毒，揭示其在灵长类中持续转座
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
转座元件可在基因组内移动，偶尔也会从宿主跳到病毒。研究者在人类痘病毒——传染性软疣病毒（MCV）中发现两处人类BC200非编码RNA基因的插入，推测是在现代人类历史时期通过长散布核元件1（LINE-1或L1）介导的逆转座获得。BC200约4000万年前被招募来调控神经元翻译，但研究显示它从未丧失移动能力，而是作为L1介导的生殖系逆转座的“主源”，在类人猿演化中产生数百个谱系特异性插入。此外BC200还在人群中产生插入多态性，包括提示仍在持续转座的个体特异性插入。因此BC200模糊了基因与转座子的界限，并实现了向人类痘病毒的近期逃逸。
为什么推荐给您：首次发现人类非编码基因近期转座进入人类痘病毒，拓展基因与转座子界限的认识。
不需要生物学背景，多打比方
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摘要Abstract
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum contagiosum virus (MCV), which were likely acquired through long interspersed nuclear element 1 (LINE-1 or L1)-mediated retrotransposition during modern human history. Although BC200 was co-opted approximately 40 million years ago to regulate neuronal translation, we show that it never lost its mobilization capacity. Rather, BC200 functioned as a "master" source of L1-mediated germline retrotransposition events throughout anthropoid evolution, spawning hundreds of lineage-specific insertions. Additionally, BC200 has produced insertion polymorphisms segregating in the human population, including individual-specific insertions indicative of ongoing transposition activity. Thus, BC200 blurs the line between gene and transposon, combining stable function with persistent mobilization, including a recent escape into a human poxvirus.